Summary The interleukin‐1 (IL‐1) family of cytokines and receptors is unique in immunology
because the IL‐1 family and Toll‐like receptor (TLR) families share similar functions. More …

Together with IL-12 or IL-15, interleukin-18 (IL-18) plays a major role in the production of
interferon-γ from T-cells and natural killer cells; thus, IL-18 is considered to have a major role …

Abstract Interleukin 18 (IL-18) is a proinflammatory cytokine in the IL-1 family that has been
implicated in a number of disease states. In animal models of acute myocardial infarction …

The main drivers of acute inflammation are macrophages, which are known to have
receptors for catecholamines. Based on their function, macrophages are broadly …

Natural soluble antagonist and decoy receptor on the surface of the cell membrane are
evolving as crucial immune system regulators as these molecules are capable of …

Cyclic nucleotide phosphodiesterase 1C (PDE1C) represents a major phosphodiesterase
activity in human myocardium, but its function in the heart remains unknown. Using genetic …

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition that can
lead to atrial fibrillation, heart failure, and sudden cardiac death in many individuals but mild …

Background Activation of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3)
inflammasome contributes to heart failure (HF) pathogenesis. However, the effect of NLRP3 …

Background: Over the last decades, the role of inflammation and immune system activation
in the initiation and progression of coronary artery disease (CAD) has been established …

Abstract Interleukin (IL)-18 and IL-22 are key components of cytokine networks that play a
decisive role in (pathological) inflammation, host defense, and tissue regeneration. Tight …