More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Lens epithelium–derived growth factor (LEDGF/p75) is a cellular cofactor of HIV-1 integrase
that promotes viral integration by tethering the preintegration complex to the chromatin. By …

New genetic tools are needed to understand the functional interactions between HIV and
human host factors in primary cells. We recently developed a method to edit the genome of …

Chromosomal integration enables human immunodeficiency virus (HIV) to establish a
permanent reservoir that can be therapeutically suppressed but not eradicated. Participation …

LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …

Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

Abstract Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA
copy of their genome after entry into the host cell. Integration of this DNA into the host cell's …

Background To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA
genomes into host cell chromosomes. Lentiviral integration is favored in active transcription …

Background The human immunodeficiency virus type 1 (HIV-1) and other lentiviruses have
the capacity to infect nondividing cells like macrophages. This requires import of the …