Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …

Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that
appear to spread throughout the brain via a cell-to-cell transmission process that includes …

The microtubule-associated protein Tau plays a central role in the pathogenesis of
Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of …

Microtubules are regulated by microtubule‐associated proteins. However, little is known
about the structure of microtubule‐associated proteins in complex with microtubules. Herein …

Tau protein (MAPT) is classified as a microtubule-associated protein (MAP) and is believed
to regulate the axonal microtubule arrangement. It belongs to the tau/MAP2/MAP4 family of …

Tau is a neuronal microtubule-associated protein (MAP) that is involved in the regulation of
axonal microtubule assembly. However, as a protein with intrinsically disordered regions …

Tau misfolding and assembly is linked to a number of neurodegenerative diseases
collectively described as tauopathies, including Alzheimer's disease (AD) and Parkinson's …

PICALM, a clathrin adaptor protein, plays important roles in clathrin-mediated endocytosis in
all cell types. Recently, genome-wide association studies identified single nucleotide …

In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …