Disease-associated oligodendroglia: a putative nexus in neurodegeneration

G Castelo-Branco, P Kukanja, AO Guerreiro-Cacais… - Trends in …, 2024 - cell.com
Neural cells in our central nervous system (CNS) have long been thought to be mere targets
of neuroinflammatory events in neurodegenerative diseases such as multiple sclerosis (MS) …

Development and function of the medial amygdala

N Prakash, AA Irqeba, JG Corbin - Trends in Neurosciences, 2024 - cell.com
Across studied vertebrates, the medial amygdala (MeA) is a central hub for relaying sensory
information with social and/or survival relevance to downstream nuclei such as the bed …

A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types

Y Ben-Simon, M Hooper, S Narayan, T Daigle… - …, 2024 - pmc.ncbi.nlm.nih.gov
The mammalian cortex is comprised of cells classified into types according to shared
properties. Defining the contribution of each cell type to the processes guided by the cortex …

Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution

K Ciuba, A Piotrowska, D Chaudhury, B Dehingia… - Cell Stem Cell, 2023 - cell.com
Astrocytes contribute to the development and regulation of the higher-level functions of the
brain, the critical targets of evolution. However, how astrocytes evolve in primates is …

mRNA stability fine-tunes gene expression in the develo** cortex to control neurogenesis

LD Serdar, JR Egol, B Lackford, BD Bennett, G Hu… - PLoS …, 2025 - journals.plos.org
RNA abundance is controlled by rates of synthesis and degradation. Although mis-
regulation of RNA turnover is linked to neurodevelopmental disorders, how it contributes to …

A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro

D Medina-Cano, MT Islam, V Petrova, S Dixit, Z Balic… - bioRxiv, 2024 - biorxiv.org
Natural selection has shaped the gene regulatory networks that orchestrate the
development of the neocortex, leading to diverse neocortical structure and function across …

[HTML][HTML] Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids

M Nishimura, T Kodera, S Adachi, AY Sato… - Neuroscience …, 2024 - Elsevier
Despite the crucial role of synaptic connections and neural activity in the development and
organization of cortical circuits, the mechanisms underlying the formation of functional …

Early Developmental Origins of Cortical Disorders Modeled in Human Neural Stem Cells

X Mato-Blanco, SK Kim, A Jourdon, S Ma… - …, 2024 - pmc.ncbi.nlm.nih.gov
The implications of the early phases of human telencephalic development, involving neural
stem cells (NSCs), in the etiology of cortical disorders remain elusive. Here, we explored the …

Temporal and Notch identity determine layer targeting and synapse location of medulla neurons

I Holguera, YC Chen, YCD Chen, F Simon, AG Gaffney… - bioRxiv, 2025 - biorxiv.org
How specification mechanisms that generate neural diversity translate into specific neuronal
targeting, connectivity, and function in the adult brain is not understood. In the medulla …

[CITACE][C] Simple and reproducible directed differentiation of cortical neural cells from hiPSCs in chemically defined media for toxicological studies

H Kim, D Yi, AB Bowman - 2024 - Elsevier