At the crossroads of immunotherapy for oncogene-addicted subsets of NSCLC
I Otano, AC Ucero, J Zugazagoitia… - Nature reviews Clinical …, 2023 - nature.com
Non-small-cell lung cancer (NSCLC) has become a paradigm of precision medicine, with
the discovery of numerous disease subtypes defined by specific oncogenic driver mutations …
the discovery of numerous disease subtypes defined by specific oncogenic driver mutations …
Harnessing big data to characterize immune-related adverse events
Immune-checkpoint inhibitors (ICIs) have transformed patient care in oncology but are
associated with a unique spectrum of organ-specific inflammatory toxicities known as …
associated with a unique spectrum of organ-specific inflammatory toxicities known as …
Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis
Z Xun, X Ding, Y Zhang, B Zhang, S Lai, D Zou… - Nature …, 2023 - nature.com
Although advances in spatial transcriptomics (ST) enlarge to unveil spatial landscape of
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
A review of deep learning techniques for lung cancer screening and diagnosis based on CT images
One of the most common and deadly diseases in the world is lung cancer. Only early
identification of lung cancer can increase a patient's probability of survival. A frequently used …
identification of lung cancer can increase a patient's probability of survival. A frequently used …
Helicobacter pylori and immunotherapy for gastrointestinal cancer
K Jia, Y Chen, Y **e, X Wang, Y Hu, Y Sun, Y Cao… - The Innovation, 2024 - cell.com
Helicobacter pylori infection is associated with the risk of gastrointestinal (GI) cancers;
however, its impact on immunotherapy for GI cancers remains uncertain. In this study, we …
however, its impact on immunotherapy for GI cancers remains uncertain. In this study, we …
[HTML][HTML] Leveraging high-resolution omics data for predicting responses and adverse events to immune checkpoint inhibitors
A long-standing goal of personalized and precision medicine is to enable accurate
prediction of the outcomes of a given treatment regimen for patients harboring a disease …
prediction of the outcomes of a given treatment regimen for patients harboring a disease …
New insights into the biology and development of lung cancer in never smokers—implications for early detection and treatment
Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers
comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is …
comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is …
Genetic, pharmacogenomic, and immune landscapes of enhancer RNAs across human cancers
Enhancer RNAs (eRNA) regulate gene expression and play critical roles in cancer. Using
large-scale omics data from The Cancer Genome Atlas (TCGA), we systematically …
large-scale omics data from The Cancer Genome Atlas (TCGA), we systematically …
Identification of Hypoxia‐ALCAMhigh Macrophage‐ Exhausted T Cell Axis in Tumor Microenvironment Remodeling for Immunotherapy Resistance
Z Xun, H Zhou, M Shen, Y Liu, C Sun, Y Du… - Advanced …, 2024 - Wiley Online Library
Although hypoxia is known to be associated with immune resistance, the adaptability to
hypoxia by different cell populations in the tumor microenvironment and the underlying …
hypoxia by different cell populations in the tumor microenvironment and the underlying …
Characterization of immune-related alternative polyadenylation events in cancer immunotherapy
Alternative polyadenylation (APA) is an important posttranscriptional modification commonly
involved in tumor development. However, the functional roles of APA in tumor immunity …
involved in tumor development. However, the functional roles of APA in tumor immunity …