Molecular and biochemical regulation of skeletal muscle metabolism

MD Zumbaugh, SE Johnson, TH Shi… - Journal of Animal …, 2022 - academic.oup.com
Skeletal muscle hypertrophy is a culmination of catabolic and anabolic processes that are
interwoven into major metabolic pathways, and as such modulation of skeletal muscle …

A glutathione activatable ion channel induces apoptosis in cancer cells by depleting intracellular glutathione levels

JA Malla, RM Umesh, S Yousf, S Mane… - Angewandte Chemie …, 2020 - Wiley Online Library
Cancer cells use elevated glutathione (GSH) levels as an inner line of defense to evade
apoptosis and develop drug resistance. In this study, we describe a novel 2, 4 …

The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders

Y Liu, Y Wu, M Jiang - Frontiers in Physiology, 2022 - frontiersin.org
Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1
(PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is …

[HTML][HTML] Cadmium perturbed metabolomic signature in pancreatic beta cells correlates with disturbed metabolite profile in human urine

H Hong, J Xu, H He, X Wang, L Yang, P Deng… - Environment …, 2022 - Elsevier
Cd exposure has been demonstrated to induce a variety of metabolic disorders
accompanied with imbalance of glucose and lipid homeostasis. The metabolic toxicity of Cd …

Integrated metabolome and transcriptome analyses revealing the effects of thermal stress on lipid metabolism in juvenile turbot Scophthalmus maximus

T Zhao, A Ma, S Yang, Z Huang - Journal of Thermal Biology, 2021 - Elsevier
To gain insights into the influence of heat stress on lipid metabolism in juvenile turbot
(Scophthalmus maximus), we analyzed the correlations between data obtained by …

Potential obesogenic effects of TBBPA and its alternatives TBBPS and TCBPA revealed by metabolic perturbations in human hepatoma cells

Y Yu, C Hao, M **ang, J Tian, H Kuang, Z Li - Science of The Total …, 2022 - Elsevier
To date, increasing numbers of studies have shown the obesogenic effects of
tetrabromobisphenol A (TBBPA). Tetrabromobisphenol S (TBBPS) and tetrachlorobisphenol …

Metabolic profiles point out metabolic pathways pivotal in two glioblastoma (GBM) cell lines, U251 and U-87MG

F Martins, D van der Kellen, LG Gonçalves, J Serpa - Biomedicines, 2023 - mdpi.com
Glioblastoma (GBM) is the most lethal central nervous system (CNS) tumor, mainly due to its
high heterogeneity, invasiveness, and proliferation rate. These tumors remain a therapeutic …

A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics

NG Bliziotis, UFH Engelke, RLEG Aspers, J Engel… - Metabolomics, 2020 - Springer
Introduction When analyzing the human plasma metabolome with Nuclear Magnetic
Resonance (NMR) spectroscopy, the Carr–Purcell–Meiboom–Gill (CPMG) experiment is …

Human Pancreatic Islets React to Glucolipotoxicity by Secreting Pyruvate and Citrate

J Perrier, M Nawrot, AM Madec, K Chikh, MA Chauvin… - Nutrients, 2023 - mdpi.com
Progressive decline in pancreatic beta-cell function is central to the pathogenesis of type 2
diabetes (T2D). Here, we explore the relationship between the beta cell and its nutritional …

Esterase‐Activatable Synthetic M+/Cl Channel Induces Apoptosis and Disrupts Autophagy in Cancer Cells

JA Malla, VK Sharma, M Lahiri… - Chemistry–A European …, 2020 - Wiley Online Library
The formation of a supramolecular synthetic M+/Cl− channel in the membrane phospholipid
bilayer has been reported upon activation of a methyl pivalate‐linked N1, N3‐dialkyl‐2 …