Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Osteogenesis imperfecta is a phenotypically and molecularly heterogeneous group of
inherited connective tissue disorders that share similar skeletal abnormalities causing bone …

Recently, the genetic heterogeneity in osteogenesis imperfecta (OI), proposed in 1979 by
Sillence et al., has been confirmed with molecular genetic studies. At present, 17 genetic …

Osteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous skeletal
dysplasia characterized by bone fragility, growth deficiency, and skeletal deformity …

Osteogenesis imperfecta is a genetic disorder characterized by low bone mass, decreased
bone strength, increased bone fragility, and shortened stature. Autosomal dominant …

Osteoporosis is a metabolic bone disorder that is characterized by low bone mass and micro-
architectural deterioration of bone tissue. Fractures of the proximal femur, the vertebrae and …

The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

Osteoporosis is a common disorder, affecting hundreds of millions of people worldwide, and
characterized by decreased bone mineral density and increased fracture risk. Known …

Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …