Key Points Cryptococcal Disease in Diverse Hosts Worldwide, cryptococcal meningitis kills
up to 180,000 persons annually and is the most common cause of nonviral meningitis in the …

Cryptococcosis is a major worldwide disseminated invasive fungal infection. Cryptococcosis,
particularly in its most lethal manifestation of cryptococcal meningitis, accounts for …

Background Cryptococcal meningitis is the most common cause of meningitis in adults living
with HIV in sub-Saharan Africa. The estimates of national, regional, and global burden of …

Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected
persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg) …

Cryptococcal meningitis is a leading cause of morbidity and mortality globally, especially in
people with advanced HIV disease. Cryptococcal meningitis is responsible for nearly 20% of …

Recent advances in the diagnosis and management of cryptococcal meningitis are
promising and have been improving long-term survival. Point of care testing has made …

Background Identifying new antifungals for cryptococcal meningitis is a priority given the
inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity …

Cryptococcal meningoencephalitis was first described over a century ago. This fungal
infection is preventable and treatable yet continues to be associated with excessive …

The global burden of infections due to the pathogenic fungus Cryptococcus is substantial in
persons with low CD4+ T-cell counts. Previously, we deleted three chitin deacetylase genes …