Nearly a century of research has shown that nutritional interventions can delay aging and
age-related diseases in many animal models and possibly humans. The most robust and …

Evaluation of behavior and cognition in rodent models underpins mechanistic and
interventional studies of brain aging and neurodegenerative diseases, especially dementia …

Nutrient sensing pathways influence metabolic health and aging, offering the possibility that
diet might be used therapeutically, alone or with drugs targeting these pathways. We used …

Old age is the greatest risk factor for most neurodegenerative diseases. During recent
decades there have been major advances in understanding the biology of aging, and the …

Current thinking in life‐history theory and the biology of ageing suggests that ageing rates,
and consequently life spans, evolve largely as a function of trade‐offs with reproduction …

Increase in the aging population is a phenomenon all over the world. Maintaining good
functional ability, good mental health, and cognitive function in the absence of severe …

Diet and nutrition comprise a complex, multi-faceted interface between animal biology and
food environments. With accumulating information on the many facets of this association …

Fundamental questions in nutrition include,“What constitutes a nutritionally balanced
diet?”,“What are the consequences of failing to achieve diet balance?”, and “How does diet …

Highlights•Optimal foraging theory and nutritional ecology developed largely
independently.•The nutritional geometry framework can integrate these fields.•This …

Nutrition profoundly influences the risk for many age‐related diseases. Whether nutrition
influences human aging biology directly is less clear. Studies in different animal species …