Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets
including CD4+, NK, and γδ T cells beyond conventional CD8+ CTLs. However, definitive …

Neurodegenerative diseases are a group of pathological conditions that cause motor
incordination (jerking movements), cognitive and memory impairments result from …

Background Breast cancer is defined as a biological and molecular heterogeneous disorder
that originates from breast cells. Genetic predisposition is the most important factor giving …

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state
of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion …

The two major subsets of peripheral T cells are classically divided into the CD4+ T helper
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …

Abstract The CD4+ and CD8+ T cell dichotomy is essential for effective cellular immunity.
How individual T cell identity is established remains poorly understood. Here we show that …

The differentiation of T helper cell subsets and their acquisition of effector functions are
accompanied by changes in gene expression programmes, which in part are regulated and …

Histone deacetylase (HDAC) is one of the most characterized epigenetic modifiers,
modulating chromatin structure and gene expression, which plays an important role in cell …