Introduction As highly active antiretroviral therapy (HAART) transforms human
immunodeficiency virus (HIV) into a manageable chronic disease, new challenges are …

Efavirenz is a highly effective HIV-1 antiretroviral; however, it is also frequently associated
with neuropsychiatric adverse events (NPAE) that include abnormal dreams, sleep …

Introduction High levels of adherence to antiretroviral therapy (ART) are central to HIV
management. The objective of this study was to compare multiple measures of adherence …

The antiretroviral drug efavirenz remains widely used in children and mothers during
breastfeeding in tuberculosis‐endemic areas. Evaluating the safety of efavirenz during …

Aim: To encapsulate efavirenz (EFV) within poly (epsilon-caprolactone)(PCL) nanoparticles
(NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure …

Objectives To evaluate antiretroviral drug concentrations in mothers and infants enrolled
under the Option B-Plus approach for the prevention of HIV mother-to-child transmission in …

The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) is the
flagship paediatric programme of the International AIDS Society (IAS), aimed at optimizing …

Background: Owing to insufficient evidence in children, target plasma concentrations of
efavirenz are based on studies in adults. Our analysis aimed to evaluate the pediatric …

Objective To investigate the influence of CYP2B6 516G> T polymorphism, as a covariate,
and of interoccasion variability (IOV) on the oral clearance (CL/F) of efavirenz (EFV) in …

This study evaluated mid-dosing interval efavirenz plasma concentrations and the influence
of CYP2B6 polymorphisms in relation to efficacy, tolerability, and adherence in 97 Rwandan …