In this review an overview about biological applications of magnetic colloidal nanoparticles
will be given, which comprises their synthesis, characterization, and in vitro and in vivo …

Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is
exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor …

Skin-derived dendritic cells (DCs) play a crucial role in the maintenance of immune
homeostasis due to their role in antigen trafficking from the skin to the draining lymph nodes …

The brain is a specialized immune site representing a unique tumor microenvironment. The
availability of fresh brain tumor material for ex vivo analysis is often limited because large …

Background More than 200 clinical trials have been performed using dendritic cells (DC) as
cellular adjuvants in cancer. Yet the key question whether there is a link between immune …

The use of tumor-associated antigen (TAA) mRNA for therapeutic purposes is under active
investigation. To be effective, mRNA vaccines need to deliver activation stimuli in addition to …

Cancer immunotherapy has been proposed as a powerful treatment modality. Active
immunotherapy aspires to stimulate the patient's immune system, particularly T cells. These …

An intact immune system is essential to prevent the development and progression of
neoplastic cells in a process termed immune surveillance. During this process the innate …

Purpose: A critical factor determining the effectiveness of currently used dendritic cell (DC)–
based vaccines is the DC activation or maturation status. We have recently shown that the T …