Increased life expectancy coupled with declining birth rates is leading to an aging
population structure. Aging-caused changes, such as physical or cognitive decline, could …

Alzheimer's disease (AD) is a severe neurodegenerative disease with slow course of onset
and deterioration with time. With the speedup of global aging, AD has become a disease …

This paper proposes a filter-based feature selection method by combining the measurement
of kernel canonical correlation analysis (KCCA) with the mutual information (MI)-based …

Outcome-wide analysis can offer several benefits, including increased power to detect weak
signals and the ability to identify exposures with multiple effects on health, which may be …

Translational research in neuroscience is increasingly focusing on the analysis of multi-
modal data, in order to account for the biological complexity of suspected disease …

Single nucleotide polymorphisms (SNPs) are one type of genetic variations and each SNP
represents a difference in a single DNA building block, namely a nucleotide. Previous …

Population aged 60 and over is growing faster. Ageing-caused changes, such as physical or
cognitive decline, could affect people's quality of life, resulting in injuries, mental health or …

In this thesis, we propose an exact solution path algorithm of Generalized Lasso when the
design matrix $ X $ is non-full rank.\newline In the case of non-full rank, the conventional …

Large-scale ℓ 1-regularized loss minimization problems arise in high-dimensional
applications such as compressed sensing and high-dimensional supervised learning …