Physiology of microglia
H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …
Molecular structure and physiological function of chloride channels
TJ Jentsch, V Stein, F Weinreich… - Physiological …, 2002 - journals.physiology.org
Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …
Intracellular chloride channels: novel biomarkers in diseases
Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …
intracellular membranes. In the human genome, there are more than 400 known genes …
[HTML][HTML] Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic …
M Peretti, M Angelini, N Savalli, T Florio… - … et Biophysica Acta (BBA …, 2015 - Elsevier
In recent decades, growing scientific evidence supports the role of ion channels in the
development of different cancers. Both potassium selective pores and chloride …
development of different cancers. Both potassium selective pores and chloride …
The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition
Most proteins adopt a well defined three-dimensional structure; however, it is increasingly
recognized that some proteins can exist with at least two stable conformations. Recently, a …
recognized that some proteins can exist with at least two stable conformations. Recently, a …
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide …
Background Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma
proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting …
proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting …
[HTML][HTML] The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?
Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that
they have both soluble and integral membrane forms. CLICs are highly conserved in …
they have both soluble and integral membrane forms. CLICs are highly conserved in …
Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-Å resolution
CLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that
exists in both soluble and integral membrane forms. Purified CLIC1 can integrate into …
exists in both soluble and integral membrane forms. Purified CLIC1 can integrate into …
[HTML][HTML] Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human
glioblastoma stem cells, via inhibition of CLIC1-mediated ion current - PMC Back to Top Skip to …
glioblastoma stem cells, via inhibition of CLIC1-mediated ion current - PMC Back to Top Skip to …
Anion channels of mitochondria
Mitochondria are the “power house” of a cell continuously generating ATP to ensure its
proper functioning. The constant production of ATP via oxidative phosphorylation demands …
proper functioning. The constant production of ATP via oxidative phosphorylation demands …