By forming extended hydrogen-bond networks, the contribution of hydroxyl groups to affinity
can reach several orders of magnitude. However, because of the high directionality of their …

ABSTRACT Introduction: The bacterial adhesin FimH is a virulence factor and an attractive
therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type …

Multivalent carbohydrate–lectin interactions at host–pathogen interfaces play a crucial role
in the establishment of infections. Although competitive antagonists that prevent pathogen …

Gram-negative uropathogenic Escherichia coli (UPEC) bacteria are a causative pathogen of
urinary tract infections (UTIs). Previously developed antivirulence inhibitors of the type 1 …

The rapid development of antimicrobial resistance is threatening mankind to such an extent
that the World Health Organization expects more deaths from infections than from cancer in …

Biofilm formation by most pathogenic bacteria is considered as one of the key mechanisms
associated with virulence and antibiotic resistance. Biofilm-forming bacteria adhere to the …

Uropathogenic E. coli (UPEC) employ the mannose‐binding adhesin FimH to colonize the
bladder epithelium during urinary tract infection (UTI). Previously reported FimH antagonists …

Type 1 fimbriae are responsible for bacterial pathogenicity and biofilm production, which are
important virulence factors in uropathogenic Escherichia coli strains. Many articles are …

Microbial adhesion is an essential step in infection and is mediated primarily by protein–
carbohydrate interactions. Antagonists of such interactions have become a promising target …

Urinary tract infections (UTIs) affect nearly 50% of women in their lifetime. Uropathogenic
Escherichia coli (UPEC) expresses F9/Fml pili tipped with the protein FmlH that specifically …