Tumor cells possess complex immune evasion mechanisms to evade immune system
attacks, primarily through metabolic reprogramming, which significantly alters the tumor …

Through novel methodologies, including both basic and clinical research, progress has
been made in the therapy of solid cancer. Recent innovations in anticancer therapies …

Glioblastoma (GBM) is an aggressive and highly malignant primary brain tumor
characterized by rapid growth and a poor prognosis for patients. Despite advancements in …

Hypoxia is a common feature of most solid tumors, which promotes the proliferation,
invasion, metastasis, and therapeutic resistance of tumors. Researchers have been …

The surrounding non-cancer cells and tumor cells that make up the tumor microenvironment
(TME) have various metabolic rhythms. TME metabolic heterogeneity is influenced by the …

Abstract Objectives Glucose transporter 3 (GLUT3) plays a major role in glycolysis and
glucose metabolism in cancer cells. We aimed to investigate the correlation between GLUT3 …

X-ray-induced photodynamic therapy (X-PDT) leverages the penetration power of X-rays to
generate reactive oxygen species (ROS) within deep tissues for cancer treatment, merging …

Precise targeted delivery of therapeutic agents is crucial for tumor therapy. As an emerging
fashion, cell-based delivery provides better biocompatibility and lower immunogenicity and …

Pyruvate kinase isoform M2 (PKM2) is a multifunctional enzyme capable of transitioning
between monomeric, dimeric, and tetrameric states, with its oligomeric equilibrium playing a …

In contrast to normal cells, cancer cells predominantly utilise glycolysis for ATP generation
under aerobic conditions, facilitating proliferation and metastasis. Targeting glycolysis is …