Network pharmacology: curing causal mechanisms instead of treating symptoms
For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …
discovery is in constant decline. While low quality, reproducibility issues, and translational …
Network pharmacology approach for medicinal plants: review and assessment
Natural products have played a critical role in medicine due to their ability to bind and
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …
Network medicine framework for identifying drug-repurposing opportunities for COVID-19
D Morselli Gysi, Í Do Valle, M Zitnik… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
Network pharmacology approaches for research of Traditional Chinese Medicines
LI **ang, LIU Ziqi, L Jie, C Qian, LU **aoyan… - Chinese Journal of …, 2023 - Elsevier
Pharmacodynamics material basis and effective mechanisms are the two main issues to
decipher the mechnisms of action of Traditional Chinese medicines (TCMs) for the treatment …
decipher the mechnisms of action of Traditional Chinese medicines (TCMs) for the treatment …
DrugMAP: molecular atlas and pharma-information of all drugs
The efficacy and safety of drugs are widely known to be determined by their interactions with
multiple molecules of pharmacological importance, and it is therefore essential to …
multiple molecules of pharmacological importance, and it is therefore essential to …
A comprehensive application: Molecular docking and network pharmacology for the prediction of bioactive constituents and elucidation of mechanisms of action in …
Traditional Chinese medicine (TCM) has been used for more than 2000 years in China.
TCM has received wide attention recently due to its unique charm. At the same time, its main …
TCM has received wide attention recently due to its unique charm. At the same time, its main …
Molecular networks in Network Medicine: Development and applications
EK Silverman, HHHW Schmidt… - … Systems Biology and …, 2020 - Wiley Online Library
Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
pathogenesis. Many different analytical methods have been used to infer relevant molecular …
Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine
HY Yang, ML Liu, P Luo, XS Yao, H Zhou - Phytomedicine, 2022 - Elsevier
Background The field of network pharmacology showed significant development. The
concept of network pharmacology has many similarities to the philosophy of traditional …
concept of network pharmacology has many similarities to the philosophy of traditional …
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
Abstract Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by the
SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection …
SARS-CoV-2 virus. Various studies exist about the molecular mechanisms of viral infection …
Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway
Y Wei, Y Fan, Y Ga, Y Zhang, J Han, Z Hao - Phytomedicine, 2021 - Elsevier
Background Shaoyao decoction (SYD), a traditional Chinese medicine prescription that
originated in the **-Yuan Dynasty, has shown effects in treating ulcerative colitis. However …
originated in the **-Yuan Dynasty, has shown effects in treating ulcerative colitis. However …