Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

Pacemaker activity of spontaneously active neurons,, and heart cells,, is controlled by a
depolarizing, mixed Na+/K+ current, named I h (or I f in the sinoatrial node of the heart),. This …

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that
activates neurons via generation of brief pulses of high-intensity magnetic field. If these …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

Production of energy for the maintenance of ionic disequilibria necessary for generation and
transmission of nerve impulses is one of the primary functions of the brain. This review …

Inhibition of" leak" potassium (K+) channels is a widespread CNS mechanism by which
transmitters induce slow excitation. We show that TASK-1, a two pore domain K+ channel …

Hyperpolarization-activated cation currents, termed Ih, are observed in a variety of neurons.
Four members of a gene family encoding h yperpolarization-activated c yclic-n ucleotide …

Various subsets of brain neurons express a hyperpolarization-activated inward current (I h)
that has been shown to be instrumental in pacing oscillatory activity at both a single-cell and …

Schizophrenia is a disorder in which disturbances in the integration of emotion with
cognition plays a central role and probably involves several different regions, including the …