Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …

Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …

The design and synthesis of novel fluorescent heterocyclic dyes is a “hotspot” research area,
due to their favourable photophysical properties and crucial role in charge transfer …

DNA topoisomerase II (topo II) is an important enzyme involved in DNA replication,
recombination, and repair. Despite the popular applications of topo II inhibitors in cancer …

The search for new anticancer agents is considered a dynamic field of medicinal chemistry.
In recent years, the synthesis of compounds with anticancer potential has increased and a …

To exploit the advantageous properties of approved drugs to hasten anticancer drug
discovery, we designed and synthesized a series of fluoroquinolone (FQ) analogs via …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Isatin derivatives potentially act on various biological targets. In this article, a series of novel
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …

Aim: This paper aims to describe the structure activity relationship of heterocyclic derivatives
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …

In order to develop potent anticaner agents, a novel series of 3-(1H-indol-3-yl)-2, 3, 3a, 4-
tetrahydrothiochromeno [4, 3-c] pyrazole derivatives were synthesized. Structures of all …