Tumour-intrinsic resistance to immune checkpoint blockade
Abstract 'Immune checkpoint blockade'for cancer describes the use of therapeutic antibodies
that disrupt negative immune regulatory checkpoints and unleash pre-existing antitumour …
that disrupt negative immune regulatory checkpoints and unleash pre-existing antitumour …
The immune contexture in cancer prognosis and treatment
Immunotherapy is currently the most rapidly advancing area of clinical oncology, and
provides the unprecedented opportunity to effectively treat, and even cure, several …
provides the unprecedented opportunity to effectively treat, and even cure, several …
Cytotoxic CD4+ T cells in cancer: expanding the immune effector toolbox
DY Oh, L Fong - Immunity, 2021 - cell.com
Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …
Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms
Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …
Predictive biomarkers for checkpoint inhibitor-based immunotherapy
GT Gibney, LM Weiner, MB Atkins - The Lancet Oncology, 2016 - thelancet.com
The clinical development of checkpoint inhibitor-based immunotherapy has ushered in an
exciting era of anticancer therapy. Durable responses can be seen in patients with …
exciting era of anticancer therapy. Durable responses can be seen in patients with …
Acquired resistance to immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have rapidly altered the treatment landscape for multiple
tumor types, providing unprecedented survival in some patients. Despite the characteristic …
tumor types, providing unprecedented survival in some patients. Despite the characteristic …
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but
predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study …
predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study …
Identification of bacteria-derived HLA-bound peptides in melanoma
S Kalaora, A Nagler, D Nejman, M Alon, C Barbolin… - Nature, 2021 - nature.com
A variety of species of bacteria are known to colonize human tumours,,,,,,,,,–, proliferate
within them and modulate immune function, which ultimately affects the survival of patients …
within them and modulate immune function, which ultimately affects the survival of patients …
Mechanisms of immune activation and regulation: lessons from melanoma
Melanoma, a skin cancer that develops from pigment cells, has been studied intensively,
particularly in terms of the immune response to tumours, and has been used as a model for …
particularly in terms of the immune response to tumours, and has been used as a model for …
The tumor microenvironment in the response to immune checkpoint blockade therapies
Tumor cells constantly interact with their microenvironment, which comprises a variety of
immune cells together with endothelial cells and fibroblasts. The composition of the tumor …
immune cells together with endothelial cells and fibroblasts. The composition of the tumor …