Physical activity (PA) has been central in the life of our species for most of its history, and
thus shaped our physiology during evolution. However, only recently the health …

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

Proteases, including intracellular proteases, play roles at many different stages of malignant
progression. Our focus here is cathepsin B, a lysosomal cysteine cathepsin. High levels of …

The external pH of solid tumors is acidic as a consequence of increased metabolism of
glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and …

Several mechanistically distinct models of nonclassical secretion, including exocytosis of
secretory lysosomes, shedding of plasma membrane microvesicles, and direct efflux through …

Background: Analysis of global changes in gene transcription and translation by systems-
based genomics and proteomics approaches provides only indirect information about …

Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain
disorders have provided extensive evidence for involvement of cathepsin B, a lysosomal …

Alzheimer's disease (AD) may result from the accumulation of amyloid-β (Aβ) peptides in the
brain. The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD …

Lysosomes have traditionally been viewed as degradative organelles, although a growing
body of evidence suggests that they can function as Ca 2+ stores. Here we examined the …

The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …