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Blood biomarkers for Alzheimer's disease in clinical practice and trials
Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic
work-up of Alzheimer's disease (AD) in clinical practice. This is very timely, considering the …
work-up of Alzheimer's disease (AD) in clinical practice. This is very timely, considering the …
Neurofilaments as biomarkers in neurological disorders—towards clinical application
Neurofilament proteins have been validated as specific body fluid biomarkers of neuro-
axonal injury. The advent of highly sensitive analytical platforms that enable reliable …
axonal injury. The advent of highly sensitive analytical platforms that enable reliable …
Plasma proteomic profiles predict future dementia in healthy adults
The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
Blood-based biomarkers for Alzheimer's disease: towards clinical implementation
For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but
recent results have shown that they could become a reality. Convincing data generated with …
recent results have shown that they could become a reality. Convincing data generated with …
Blood‐based biomarkers for Alzheimer's disease
Neurodegenerative disorders such as Alzheimer's disease (AD) represent a mounting public
health challenge. As these diseases are difficult to diagnose clinically, biomarkers of …
health challenge. As these diseases are difficult to diagnose clinically, biomarkers of …
Prediction of future Alzheimer's disease dementia using plasma phospho-tau combined with other accessible measures
A combination of plasma phospho-tau (P-tau) and other accessible biomarkers might
provide accurate prediction about the risk of develo** Alzheimer's disease (AD) dementia …
provide accurate prediction about the risk of develo** Alzheimer's disease (AD) dementia …
Neurofilament proteins as biomarkers to monitor neurological diseases and the efficacy of therapies
Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …
Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19
Objective To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
Serum neurofilament light levels in normal aging and their association with morphologic brain changes
Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured
not only in cerebrospinal fluid but also in serum, which allows for repeated assessments …
not only in cerebrospinal fluid but also in serum, which allows for repeated assessments …
Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls
The recent introduction of new-generation immunoassay methods allows the reliable
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …