Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

Metal-based drugs and imaging agents are extensively used in the clinic for the treatment
and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of …

The transformational impact of bioorthogonal chemistries has inspired new strategies for the
in vivo synthesis of bioactive agents through non-natural means. Among these, Pd catalysts …

Artificial metalloenzymes (ArMs) result from the incorporation of an abiotic metal cofactor
within a protein scaffold. From the earliest techniques of transition metals adsorbed on silk …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

The development of organometallic catalysis has greatly expanded the synthetic chemist
toolbox compared to only exploiting “classical” organic chemistry. Although more widely …

Platinum-containing drugs (eg, cisplatin) are among the most frequently used
chemotherapeutic agents. Their tremendous success has spurred research and …

Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the
native environment. Recently, bioorthogonal reactions have attracted considerable attention …

The field of artificial metalloenzymes (ArMs) is rapidly growing and ArMs are attracting
increasing attention, for example, in the fields of biosensing and drug therapy. Protein …

Bioorthogonal chemistry refers to any chemical reactions that can occur inside of living
systems without interfering with native biochemical processes, which has become a …