GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Congestive heart failure (HF) is a complex disease state characterized by impaired
ventricular function and insufficient peripheral blood supply. The resultant reduced blood …

Flavonols, and specially quercetin, are widely distributed in plants and are present in
considerable amounts in fruits and vegetables. In addition to their anti-oxidant effect …

Diabetes mellitus is an important and prevalent risk factor for congestive heart failure.
Diabetic cardiomyopathy has been defined as ventricular dysfunction that occurs in diabetic …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Diabetic complications are among the largely exigent health problems currently.
Cardiovascular complications, including diabetic cardiomyopathy (DCM), account for more …

Ethnopharmacology relevance Nowadays, there is an increase in global tendency to use
medicinal plants as preventive and therapeutic agents to manage diabetes and its long-term …

Endothelial dysfunction is an early pathophysiological feature and independent predictor of
poor prognosis in most forms of cardiovascular diseases. Epidemiological studies report an …

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