Cellular ROS production participates in various cellular functions but its accumulation
decides the cell fate. Malignant cells have higher levels of ROS and active antioxidant …

Controlling reactive oxygen species (ROS) at sustainable levels can drive multiple facets of
tumor biology, including within the cancer stem cell (CSC) population. Tight regulation of …

Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and
glutathione levels to degenerative processes and tumor suppression. By performing a …

Background Ferroptosis is a novel form of iron-dependent cell death and participates in the
malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found …

The failure in effective cancer treatment is thought to be attributed to a subpopulation of
tumor cells with stem cell-like properties. These cancer stem cells (CSCs) are intimately …

Cancer development is associated with abnormal proliferation, genetic instability, cell death
resistance, metabolic reprogramming, immunity evasion, and metastasis. These alterations …

During the progression of acute lung injury (ALI), oxidative stress and inflammatory
responses always promote each other. The datasets analyzed in this research were …

GTP cyclohydrolase (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin (BH4)
biosynthesis. The catalysis of BH4 biosynthesis is tightly regulated for physiological …

Background: Considering the role of immunity and ferroptosis in the invasion, proliferation
and treatment of cancer, it is of interest to construct a model of prognostic-related differential …

Abstract Background The Human Protein Atlas (HPA) aims to map human proteins via
multiple technologies including imaging, proteomics and transcriptomics. Access of the HPA …