Phase transitions of associative biomacromolecules
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …
biomacromolecules, provide the driving forces for the formation and compositional …
RNA and condensates: Disease implications and therapeutic opportunities
Biomolecular condensates are dynamic membraneless organelles that compartmentalize
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …
Determinants that enable disordered protein assembly into discrete condensed phases
Cells harbour numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …
Conformational properties of polymers at droplet interfaces as model systems for disordered proteins
Polymer models serve as useful tools for studying the formation and physical properties of
biomolecular condensates. In recent years, the interface dividing the dense and dilute …
biomolecular condensates. In recent years, the interface dividing the dense and dilute …
Surface tension measurement and calculation of model biomolecular condensates
The surface tension of liquid-like protein-rich biomolecular condensates is an emerging
physical principle governing the mesoscopic interior organisation of biological cells. In this …
physical principle governing the mesoscopic interior organisation of biological cells. In this …
Determinants of disordered protein co-assembly into discrete condensed phases
Cells harbor numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein and RNA-rich …
biochemical processes and perform distinct cellular functions. These protein and RNA-rich …
Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates
Biomolecular condensates are viscoelastic materials. Simulations predict that fluid-like
condensations are defined by spatially inhomogeneous organization of the underlying …
condensations are defined by spatially inhomogeneous organization of the underlying …
Linking modulation of bio-molecular phase behaviour with collective interactions
Bio-molecular condensates formed in the cytoplasm of cells are increasingly recognised as
key spatiotemporal organisers of living matter, and are implicated in a wide range of …
key spatiotemporal organisers of living matter, and are implicated in a wide range of …
Dominant energetics in multi-component bio-molecular condensates
The condensation of bio-molecules into membrane-less organelles has been shown to be
integral to biological function and malfunction in living cells. These condensed phases …
integral to biological function and malfunction in living cells. These condensed phases …
Physics of droplet regulation in biological cells
D Zwicker, OW Paulin, C ter Burg - arxiv preprint arxiv:2501.13639, 2025 - arxiv.org
Droplet formation has emerged as an essential concept for the spatiotemporal organisation
of biomolecules in cells. However, classical descriptions of droplet dynamics based on …
of biomolecules in cells. However, classical descriptions of droplet dynamics based on …