Phase transitions of associative biomacromolecules

RV Pappu, SR Cohen, F Dar, M Farag, M Kar - Chemical Reviews, 2023 - ACS Publications
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

RNA and condensates: Disease implications and therapeutic opportunities

TW Han, B Portz, RA Young, A Boija, IA Klein - Cell Chemical Biology, 2024 - cell.com
Biomolecular condensates are dynamic membraneless organelles that compartmentalize
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …

Determinants that enable disordered protein assembly into discrete condensed phases

RM Welles, KA Sojitra, MV Garabedian, B **a… - Nature Chemistry, 2024 - nature.com
Cells harbour numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …

Conformational properties of polymers at droplet interfaces as model systems for disordered proteins

J Wang, DS Devarajan, A Nikoubashman… - ACS Macro …, 2023 - ACS Publications
Polymer models serve as useful tools for studying the formation and physical properties of
biomolecular condensates. In recent years, the interface dividing the dense and dilute …

Surface tension measurement and calculation of model biomolecular condensates

J Holland, AA Castrejón-Pita, R Tuinier, DGAL Aarts… - Soft Matter, 2023 - pubs.rsc.org
The surface tension of liquid-like protein-rich biomolecular condensates is an emerging
physical principle governing the mesoscopic interior organisation of biological cells. In this …

Determinants of disordered protein co-assembly into discrete condensed phases

RM Welles, KA Sojitra, MV Garabedian, B **a, W Wang… - bioRxiv, 2023 - biorxiv.org
Cells harbor numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein and RNA-rich …

Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

T Wu, MR King, Y Qiu, M Farag, RV Pappu, MD Lew - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Biomolecular condensates are viscoelastic materials. Simulations predict that fluid-like
condensations are defined by spatially inhomogeneous organization of the underlying …

Linking modulation of bio-molecular phase behaviour with collective interactions

D Qian, H Ausserwoger, WE Arter, RM Scrutton… - bioRxiv, 2023 - biorxiv.org
Bio-molecular condensates formed in the cytoplasm of cells are increasingly recognised as
key spatiotemporal organisers of living matter, and are implicated in a wide range of …

Dominant energetics in multi-component bio-molecular condensates

D Qian, H Ausserwoger, T Sneideris, M Farag… - BioRxiv, 2023 - biorxiv.org
The condensation of bio-molecules into membrane-less organelles has been shown to be
integral to biological function and malfunction in living cells. These condensed phases …

Physics of droplet regulation in biological cells

D Zwicker, OW Paulin, C ter Burg - arxiv preprint arxiv:2501.13639, 2025 - arxiv.org
Droplet formation has emerged as an essential concept for the spatiotemporal organisation
of biomolecules in cells. However, classical descriptions of droplet dynamics based on …