Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

Cancer-associated fibroblasts (CAFs) are major components of the carcinoma
microenvironment that promote tumor progression. However, the mechanisms by which …

The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been
implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that …

INTRODUCTION The alveolar region of the lung develops in a period that spans the late
embryonic and early postnatal stages of life. An intricate series of events—including cellular …

Cell adhesion is essential in cell communication and regulation, and is of fundamental
importance in the development and maintenance of tissues. The mechanical interactions …

Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Studies of cellular mechanotransduction have converged upon the idea that cells sense
extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on …

Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …