Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules
Barriers are the hallmark of a healthy physiology, blood-brain barrier (BBB) being a tough
nut to crack for most of the antigens and chemical substances. The presence of tight …
nut to crack for most of the antigens and chemical substances. The presence of tight …
[HTML][HTML] An insight into the risk factors of brain tumors and their therapeutic interventions
Brain tumors are an abnormal growth of cells in the brain, also known as multifactorial
groups of neoplasm. Incidence rates of brain tumors increase rapidly, and it has become a …
groups of neoplasm. Incidence rates of brain tumors increase rapidly, and it has become a …
Machine learning-a new paradigm in nanoparticle-mediated drug delivery to cancerous tissues through the human cardiovascular system enhanced by magnetic field
Nanoparticle-mediated drug delivery offers a promising approach to targeted cancer
therapy, leveraging the ability of nanoparticles to deliver therapeutic agents directly to …
therapy, leveraging the ability of nanoparticles to deliver therapeutic agents directly to …
An innovative one step green supercritical CO2 process for the production of liposomes co-encapsulating both a hydrophobic and a hydrophilic compound for …
N Penoy, KL Delma, HA Tonakpon, B Grignard… - International Journal of …, 2022 - Elsevier
Budesonide and salbutamol-loaded liposomes were prepared using an innovative one step
supercritical CO 2 method without any use of organic solvents. Liposomes composed of …
supercritical CO 2 method without any use of organic solvents. Liposomes composed of …
Computational modeling of drug delivery to solid tumors: A pilot study based on a real image
This study uses a multi-scale computational model to assess drug delivery to a solid tumor
and to predict the treatment's efficacy. A geometric model of the tumor and the capillary …
and to predict the treatment's efficacy. A geometric model of the tumor and the capillary …
Effect of infusion direction on convection-enhanced drug delivery to anisotropic tissue
Y Yang, T Yuan… - Journal of the …, 2024 - royalsocietypublishing.org
Convection-enhanced delivery (CED) can effectively overcome the blood–brain barrier by
infusing drugs directly into diseased sites in the brain using a catheter, but its clinical …
infusing drugs directly into diseased sites in the brain using a catheter, but its clinical …
Effect of tissue permeability and drug diffusion anisotropy on convection-enhanced delivery
Although convection-enhanced delivery (CED) can successfully facilitate a bypass of the
blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially …
blood brain barrier, its treatment efficacy remains highly limited in clinic. This can be partially …
Convection enhanced delivery of anti-angiogenic and cytotoxic agents in combination therapy against brain tumour
W Zhan - European Journal of Pharmaceutical Sciences, 2020 - Elsevier
Convection enhanced delivery is an effective alternative to routine delivery methods to
overcome the blood brain barrier. However, its treatment efficacy remains disappointing in …
overcome the blood brain barrier. However, its treatment efficacy remains disappointing in …
Convection-enhanced delivery of antiangiogenic drugs and liposomal cytotoxic drugs to heterogeneous brain tumor for combination therapy
Simple Summary Although developed anticancer drugs have shown desirable effects in
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …
Polymersomes for Sustained Delivery of a Chalcone Derivative Targeting Glioblastoma Cells
Glioblastoma (GBM) is a primary malignant tumor of the central nervous system responsible
for the most deaths among patients with primary brain tumors. Current therapies for GBM are …
for the most deaths among patients with primary brain tumors. Current therapies for GBM are …