Challenges in the treatment of chronic wounds

RG Frykberg, J Banks - Advances in wound care, 2015 - liebertpub.com
Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg
ulcers, and pressure ulcers. They are a challenge to wound care professionals and …

Advances of hydrogel dressings in diabetic wounds

H Wang, Z Xu, M Zhao, G Liu, J Wu - Biomaterials science, 2021 - pubs.rsc.org
Currently, the treatment and care of diabetic wounds, which generally possess the
characteristics of a high amputation rate, high recurrence rate and high mortality, has …

All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

YJ Fu, YF Shi, LY Wang, YF Zhao, RK Wang… - Advanced …, 2023 - Wiley Online Library
Macrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes.
They can be divided into pro‐inflammatory macrophages (M1) and anti‐inflammatory …

The current burden of diabetic foot disease

M Edmonds, C Manu, P Vas - Journal of clinical orthopaedics and trauma, 2021 - Elsevier
Neuropathy and ischaemia are two great pathologies of the diabetic foot which lead to the
characteristic features of foot ulceration (neuropathic and ischaemic) and Charcot …

Clinical approach to chronic wound management in older adults

W Alam, J Hasson, M Reed - Journal of the American Geriatrics …, 2021 - Wiley Online Library
Older adults are at high risk of develo** chronic wounds due to numerous changes that
occur with aging. It is reasonable to consider chronic wounds as a geriatric syndrome …

Molecular complexities underlying the vascular complications of diabetes mellitus–A comprehensive review

S Paul, A Ali, R Katare - Journal of Diabetes and its Complications, 2020 - Elsevier
Diabetes is a chronic disease, characterized by hyperglycemia, which refers to the elevated
levels of glucose in the blood, due to the inability of the body to produce or use insulin …

Prevalence and risk factors of lower limb amputations in patients with diabetic foot ulcers: a systematic review and meta-analysis

BT Rodrigues, VN Vangaveti, R Urkude, E Biros… - Diabetes & Metabolic …, 2022 - Elsevier
Background and aims The study aimed at determining prevalence and risk factors (RFs) of
diabetic lower limb amputations (LLAs). Methods Electronic databases including PubMed …

Leucocyte-and platelet-rich fibrin (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: a prospective cohort study

NR Pinto, M Ubilla, Y Zamora, V Del Rio… - Platelets, 2018 - Taylor & Francis
Chronic wounds (VLU: venous leg ulcer, DFU: diabetic foot ulcer, PU: pressure ulcer, or
complex wounds) affect a significant proportion of the population. Despite appropriate …

Utility of nanomaterials in wound management

KK Sahu, M Kaurav, P Bhatt, S Minz, M Pradhan… - … Aspects for Next …, 2024 - Elsevier
Wound healing is a complex and dynamic process and its treatment requires advanced
nanotherapeutics. In the past few years, nanostructures have emerged as an innovative and …

Prevention and management strategies for diabetic neuropathy

S Smith, P Normahani, T Lane… - Life, 2022 - mdpi.com
Diabetic neuropathy (DN) is a common complication of diabetes that is becoming an
increasing concern as the prevalence of diabetes rapidly rises. There are several types of …