Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

A major challenge in human genetics is to identify the molecular mechanisms of trait-
associated and disease-associated variants. To achieve this, quantitative trait locus (QTL) …

RNA modification is a dynamic and reversible process regulated by a series of writers,
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …

The liver holds central roles in detoxification, energy metabolism, and whole body
homeostasis but can develop malignant phenotypes when being chronically overwhelmed …

Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS)
resulting in permanent disability, creating an urgent need to discover its underlying …

O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …

Ovarian cancer is resistant to immune checkpoint blockade (ICB) treatment. Combination of
targeted therapy and immunotherapy is a promising strategy for ovarian cancer treatment …

The cytoplasm is highly compartmentalized, but the extent and consequences of
subcytoplasmic mRNA localization in non-polarized cells are largely unknown. We …

Translation initiation is a highly regulated step needed for protein synthesis. Most cell-based
mechanistic work on translation initiation has been done using non-stressed cells growing in …

RNA-binding proteins (RBPs) play key roles in a wide range of physiological and
pathological processes. To facilitate the investigation of RBP functions and disease …