Targeting tumor-associated macrophages in cancer
P Pathria, TL Louis, JA Varner - Trends in immunology, 2019 - cell.com
Macrophages are phagocytes that serve as a first line of defense against pathogenic insults
to tissues. These innate immune cells mount proinflammatory responses to pathogens and …
to tissues. These innate immune cells mount proinflammatory responses to pathogens and …
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach
Tumor-associated macrophages (TAM) plasticity and diversity are both essential hallmarks
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …
of the monocyte-macrophage lineage and the tumor-derived inflammation. TAM exemplify …
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis
C Heichler, K Scheibe, A Schmied, CI Geppert… - Gut, 2020 - gut.bmj.com
Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and
tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is …
tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is …
Inflammation and colorectal cancer
AG Long, ET Lundsmith, KE Hamilton - Current colorectal cancer reports, 2017 - Springer
Abstract Purpose of Review Colorectal cancer (CRC) is the fourth most common cancer in
both men and women in the USA, resulting in over 55,000 deaths annually. Environmental …
both men and women in the USA, resulting in over 55,000 deaths annually. Environmental …
STAT3 in cancer: A double edged sword
The transcription factor signal transducer and activator of transcription (STAT) 3 is activated
downstream of cytokines, growth factors and oncogenes to mediate their functions under …
downstream of cytokines, growth factors and oncogenes to mediate their functions under …
STAT3 signaling in breast cancer: multicellular actions and therapeutic potential
Simple Summary Many signaling pathways are overactive in breast cancer, and among
them is the STAT3 signaling pathway. STAT3 is activated by secreted factors within the …
them is the STAT3 signaling pathway. STAT3 is activated by secreted factors within the …
Lipid metabolism and cancer immunotherapy: immunosuppressive myeloid cells at the crossroad
Cancer progression generates a chronic inflammatory state that dramatically influences
hematopoiesis, originating different subsets of immune cells that can exert pro-or anti-tumor …
hematopoiesis, originating different subsets of immune cells that can exert pro-or anti-tumor …
STAT5 is a key regulator in NK cells and acts as a molecular switch from tumor surveillance to tumor promotion
Natural killer (NK) cells are tightly regulated by the JAK–STAT signaling pathway and cannot
survive in the absence of STAT5. We now report that STAT5-deficient NK cells can be …
survive in the absence of STAT5. We now report that STAT5-deficient NK cells can be …
LPS enhances the chemosensitivity of oxaliplatin in HT29 cells via GSDMD-mediated pyroptosis
LS Wu, Y Liu, X Wang, B Xu, YL Lin… - Cancer Management …, 2020 - Taylor & Francis
Introduction Pyroptosis induced by lipopolysaccharide (LPS) is a dissolved form of cell
death. The molecular marker gasdermin D, specifically GSDMD-N, is critically required for …
death. The molecular marker gasdermin D, specifically GSDMD-N, is critically required for …
JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors
EA Irey, CM Lassiter, NJ Brady… - Proceedings of the …, 2019 - National Acad Sciences
Tumor-associated macrophages contribute to tumor progression and therapeutic resistance
in breast cancer. Within the tumor microenvironment, tumor-derived factors activate …
in breast cancer. Within the tumor microenvironment, tumor-derived factors activate …