Challenges and applications of large language models

J Kaddour, J Harris, M Mozes, H Bradley… - ar** review
X Meng, X Yan, K Zhang, D Liu, X Cui, Y Yang… - Iscience, 2024 - cell.com
This study systematically reviewed the application of large language models (LLMs) in
medicine, analyzing 550 selected studies from a vast literature search. LLMs like ChatGPT …

Medical ethics of large language models in medicine

JCL Ong, SYH Chang, W William, AJ Butte, NH Shah… - NEJM AI, 2024 - ai.nejm.org
Large language models (LLMs) have shown significant promise related to their application
in medical research, medical education, and clinical tasks. While acknowledging their …

The TRIPOD-LLM reporting guideline for studies using large language models

J Gallifant, M Afshar, S Ameen, Y Aphinyanaphongs… - Nature Medicine, 2025 - nature.com
Large language models (LLMs) are rapidly being adopted in healthcare, necessitating
standardized reporting guidelines. We present transparent reporting of a multivariable …

Foundation model for advancing healthcare: challenges, opportunities and future directions

Y He, F Huang, X Jiang, Y Nie, M Wang… - IEEE Reviews in …, 2024 - ieeexplore.ieee.org
Foundation model, trained on a diverse range of data and adaptable to a myriad of tasks, is
advancing healthcare. It fosters the development of healthcare artificial intelligence (AI) …

A future role for health applications of large language models depends on regulators enforcing safety standards

O Freyer, IC Wiest, JN Kather, S Gilbert - The Lancet Digital Health, 2024 - thelancet.com
Among the rapid integration of artificial intelligence in clinical settings, large language
models (LLMs), such as Generative Pre-trained Transformer-4, have emerged as …