Toxoplasma gondii infection and its implications within the central nervous system

SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

EM Frickel, CA Hunter - Journal of Experimental Medicine, 2021 - rupress.org
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

The pathogenicity and virulence of Toxoplasma gondii

SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

Emergent actin flows explain distinct modes of gliding motility

CL Hueschen, L Segev-Zarko, JH Chen, MA LeGros… - Nature Physics, 2024 - nature.com
During host infection, Toxoplasma gondii and related unicellular parasites move using
gliding, which differs fundamentally from other known mechanisms of eukaryotic cell motility …

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

J Young, C Dominicus, J Wagener… - Nature …, 2019 - nature.com
Genome-wide CRISPR screening is a powerful tool to identify genes required under
selective conditions. However, the inherent scale of genome-wide libraries can limit their …

Dense granule biogenesis, secretion, and function in Toxoplasma gondii

MB Griffith, CS Pearce… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …

High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription

S Butterworth, K Kordova, S Chandrasekaran… - Cell Host & Microbe, 2023 - cell.com
Intracellular pathogens and other endosymbionts reprogram host cell transcription to
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

A Rosenberg, LD Sibley - Cell host & microbe, 2021 - cell.com
Toxoplasma gondii translocates effector proteins into its host cell to subvert various host
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …

Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface

Y Wang, LO Sangaré… - Annual review of …, 2020 - annualreviews.org
Many intracellular pathogens, including the protozoan parasite Toxoplasma gondii, live
inside a vacuole that resides in the host cytosol. Vacuolar residence provides these …

Transport mechanisms at the malaria parasite-host cell interface

JR Beck, CM Ho - PLoS Pathogens, 2021 - journals.plos.org
Obligate intracellular malaria parasites reside within a vacuolar compartment generated
during invasion which is the principal interface between pathogen and host. To subvert their …