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Toxoplasma gondii infection and its implications within the central nervous system
SK Matta, N Rinkenberger, IR Dunay… - Nature Reviews …, 2021 - nature.com
Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …
infections in humans. Although it normally only results in mild illness in healthy individuals …
Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them
The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …
system to investigate how the immune system deals with intracellular infections. This review …
The pathogenicity and virulence of Toxoplasma gondii
SG Sanchez, S Besteiro - Virulence, 2021 - Taylor & Francis
Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …
ranging from birds to humans. While this infection is usually asymptomatic in healthy …
Emergent actin flows explain distinct modes of gliding motility
During host infection, Toxoplasma gondii and related unicellular parasites move using
gliding, which differs fundamentally from other known mechanisms of eukaryotic cell motility …
gliding, which differs fundamentally from other known mechanisms of eukaryotic cell motility …
A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice
J Young, C Dominicus, J Wagener… - Nature …, 2019 - nature.com
Genome-wide CRISPR screening is a powerful tool to identify genes required under
selective conditions. However, the inherent scale of genome-wide libraries can limit their …
selective conditions. However, the inherent scale of genome-wide libraries can limit their …
Dense granule biogenesis, secretion, and function in Toxoplasma gondii
MB Griffith, CS Pearce… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …
High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription
Intracellular pathogens and other endosymbionts reprogram host cell transcription to
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …
Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis
Toxoplasma gondii translocates effector proteins into its host cell to subvert various host
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …
pathways. T. gondii effector TgIST blocks the transcription of interferon-stimulated genes to …
Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface
Many intracellular pathogens, including the protozoan parasite Toxoplasma gondii, live
inside a vacuole that resides in the host cytosol. Vacuolar residence provides these …
inside a vacuole that resides in the host cytosol. Vacuolar residence provides these …
Transport mechanisms at the malaria parasite-host cell interface
Obligate intracellular malaria parasites reside within a vacuolar compartment generated
during invasion which is the principal interface between pathogen and host. To subvert their …
during invasion which is the principal interface between pathogen and host. To subvert their …