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The emergence and influence of internal states
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …
profoundly shape perception, cognition, and action. The neural basis of internal states, such …
Predictive processing: a canonical cortical computation
This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …
understanding cortical function in the context of emerging evidence, with a focus on sensory …
Norepinephrine links astrocytic activity to regulation of cortical state
Cortical state, defined by population-level neuronal activity patterns, determines sensory
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …
Spontaneous behaviors drive multidimensional, brainwide activity
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …
[HTML][HTML] A transcriptomic axis predicts state modulation of cortical interneurons
Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …
Single-trial neural dynamics are dominated by richly varied movements
When experts are immersed in a task, do their brains prioritize task-related activity? Most
efforts to understand neural activity during well-learned tasks focus on cognitive …
efforts to understand neural activity during well-learned tasks focus on cognitive …
Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types
Genetically encoded fluorescent voltage indicators are ideally suited to reveal the
millisecond-scale interactions among and between targeted cell populations. However …
millisecond-scale interactions among and between targeted cell populations. However …
[HTML][HTML] Ultrafast two-photon imaging of a high-gain voltage indicator in awake behaving mice
Optical interrogation of voltage in deep brain locations with cellular resolution would be
immensely useful for understanding how neuronal circuits process information. Here, we …
immensely useful for understanding how neuronal circuits process information. Here, we …
Neuromodulation of brain state and behavior
Neural activity and behavior are both notoriously variable, with responses differing widely
between repeated presentation of identical stimuli or trials. Recent results in humans and …
between repeated presentation of identical stimuli or trials. Recent results in humans and …
Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex
Rapid variations in cortical state during wakefulness have a strong influence on neural and
behavioural responses and are tightly coupled to changes in pupil size across species …
behavioural responses and are tightly coupled to changes in pupil size across species …