The emergence and influence of internal states

SW Flavell, N Gogolla, M Lovett-Barron, M Zelikowsky - Neuron, 2022 - cell.com
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Predictive processing: a canonical cortical computation

GB Keller, TD Mrsic-Flogel - Neuron, 2018 - cell.com
This perspective describes predictive processing as a computational framework for
understanding cortical function in the context of emerging evidence, with a focus on sensory …

Norepinephrine links astrocytic activity to regulation of cortical state

ME Reitman, V Tse, X Mi, DD Willoughby… - Nature …, 2023 - nature.com
Cortical state, defined by population-level neuronal activity patterns, determines sensory
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …

Spontaneous behaviors drive multidimensional, brainwide activity

C Stringer, M Pachitariu, N Steinmetz, CB Reddy… - Science, 2019 - science.org
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

[HTML][HTML] A transcriptomic axis predicts state modulation of cortical interneurons

S Bugeon, J Duffield, M Dipoppa, A Ritoux, I Prankerd… - Nature, 2022 - nature.com
Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

Single-trial neural dynamics are dominated by richly varied movements

S Musall, MT Kaufman, AL Juavinett, S Gluf… - Nature …, 2019 - nature.com
When experts are immersed in a task, do their brains prioritize task-related activity? Most
efforts to understand neural activity during well-learned tasks focus on cognitive …

Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

M Kannan, G Vasan, S Haziza, C Huang… - Science, 2022 - science.org
Genetically encoded fluorescent voltage indicators are ideally suited to reveal the
millisecond-scale interactions among and between targeted cell populations. However …

[HTML][HTML] Ultrafast two-photon imaging of a high-gain voltage indicator in awake behaving mice

V Villette, M Chavarha, IK Dimov, J Bradley, L Pradhan… - Cell, 2019 - cell.com
Optical interrogation of voltage in deep brain locations with cellular resolution would be
immensely useful for understanding how neuronal circuits process information. Here, we …

Neuromodulation of brain state and behavior

DA McCormick, DB Nestvogel… - Annual review of …, 2020 - annualreviews.org
Neural activity and behavior are both notoriously variable, with responses differing widely
between repeated presentation of identical stimuli or trials. Recent results in humans and …

Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex

J Reimer, MJ McGinley, Y Liu, C Rodenkirch… - Nature …, 2016 - nature.com
Rapid variations in cortical state during wakefulness have a strong influence on neural and
behavioural responses and are tightly coupled to changes in pupil size across species …