In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …

Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …

CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

The immune system can eliminate tumors, but checkpoints enable immune escape. Here,
we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens …

Although radiotherapy can promote antitumour immunity, the mechanisms underlying this
phenomenon remain unclear. Here, we demonstrate that the expression of the E3 ubiquitin …

Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer
(GC). Understanding the upstream regulation of immune checkpoints is crucial to further …

CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

As the clinical efficacy of immunotherapy for triple-negative breast cancer (TNBC) remains
limited, exploring new immunotherapy approaches is still indispensable. Mn 2+ has been …

Tumor-associated macrophages (TAMs) are critical in promoting tumor progression and
therapeutic resistance. In adapting to metabolic changes in the tumor microenvironment …