Glioblastoma multiforme (GBM) is a primary type of lethal brain tumor. Over the last two
decades, temozolomide (TMZ) has remained the primary chemotherapy for GBM. However …

Glioblastoma multiforme (GBM) is the most common primary brain cancer. Depression is a
common co-morbidity of this condition. Despite this common interaction, relatively little …

Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by
germline mutations in TP53. TP53 is the most common mutated gene in human cancer …

Objective ATRX is a multifunctional protein that is tightly regulated by and implicated in
transcriptional regulation and chromatin remodeling. Numerous studies have shown that …

Chemoresistance persists as a significant, unresolved clinical challenge in many cancer
types. The tumor microenvironment, in which cancer cells reside and interact with non …

Background TP53 is a master tumor suppressor gene, mutated in approximately half of all
human cancers. Given the many regulatory roles of the corresponding p53 protein, it is …

Chimeric antigen receptor T cells (CAR-T) therapy is a prospective therapeutic strategy for
blood cancers tumor, especially leukemia, but it is not effective for solid tumors …

Extraneural metastases of glioblastoma (GBM), although rare, are becoming an increasingly
recognized occurrence. Currently, the biological mechanism underlying this rare occurrence …

Sarcomas represent a heterogeneous group of mesenchymal malignancies arising at
various locations in the soft tissue and bone. Though a rare disease, sarcoma affects …

Background Gliosarcoma (GS) is a rare primary high-grade brain neoplasm with a poor
prognosis and challenging surgical resection. Although it is now considered a morphologic …