Molecular regulations of circadian rhythm and implications for physiology and diseases
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …
[HTML][HTML] When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging
An epidemic of obesity has affected large portions of the world, increasing the risk of
develo** many different age-associated diseases, including cancer, cardiovascular …
develo** many different age-associated diseases, including cancer, cardiovascular …
Importance of circadian timing for aging and longevity
Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …
can be achieved by controlling how much and/or when food is provided, as well as by …
Circadian rhythms, disease and chronotherapy
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
[HTML][HTML] Flavonoids—Natural gifts to promote health and longevity
The aging of mammals is accompanied by the progressive atrophy of tissues and organs
and the accumulation of random damage to macromolecular DNA, protein, and lipids …
and the accumulation of random damage to macromolecular DNA, protein, and lipids …
Circadian clocks in the digestive system
A Segers, I Depoortere - Nature Reviews Gastroenterology & …, 2021 - nature.com
Many molecular, physiological and behavioural processes display distinct 24-hour rhythms
that are directed by the circadian system. The master clock, located in the suprachiasmatic …
that are directed by the circadian system. The master clock, located in the suprachiasmatic …
Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming
T Sato, P Sassone‐Corsi - EMBO reports, 2022 - embopress.org
Food intake profoundly affects systemic physiology. A large body of evidence has indicated
a link between food intake and circadian rhythms, and~ 24‐h cycles are deemed essential …
a link between food intake and circadian rhythms, and~ 24‐h cycles are deemed essential …
Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice
H Inokawa, Y Umemura, A Shimba, E Kawakami… - Scientific reports, 2020 - nature.com
Modern society characterized by a 24/7 lifestyle leads to misalignment between
environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment …
environmental cycles and endogenous circadian rhythms. Persisting circadian misalignment …
Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial …
S Li, X Li, F Chen, M Liu, L Ning, Y Yan, S Zhang… - The Journal of …, 2022 - Elsevier
This study aimed to investigate the therapeutic effects of nobiletin (NOB) on nonalcoholic
steatohepatitis (NASH) and liver fibrosis in mice and to elucidate its underlying molecular …
steatohepatitis (NASH) and liver fibrosis in mice and to elucidate its underlying molecular …
Coupled network of the circadian clocks: a driving force of rhythmic physiology
The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …
beings, including humans, to anticipate and adapt to daily changes in their environment. In …