Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of
worldwide deaths, respectively, due largely to broad increased risk for disease and injury …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta …

Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …

Myelinated axons form long-range connections that enable rapid communication between
distant brain regions, but how genetics governs the strength and organization of these …

Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared
genetic basis. Traditionally, rg is studied globally, considering only the average of the …