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Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis
Familial adenomatous polyposis (FAP) is a genetic disease causing hundreds of
premalignant polyps in affected persons and is an ideal model to study transitions of early …
premalignant polyps in affected persons and is an ideal model to study transitions of early …
Do not be scared of the genome's 5th base—Explaining phenotypic variability and evolutionary dynamics through DNA methylation analysis
J Tost - Molecular Ecology Resources, 2023 - Wiley Online Library
Epigenetic processes have taken center stage for the investigation of many biological
processes, and epigenetic modifications have shown to influence phenotype, morphology …
processes, and epigenetic modifications have shown to influence phenotype, morphology …
Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis
Abstract Although three-dimensional (3D) genome architecture is crucial for gene regulation,
its role in disease remains elusive. We traced the evolution and malignant transformation of …
its role in disease remains elusive. We traced the evolution and malignant transformation of …
L0 segmentation enables data-driven concise representations of diverse epigenomic data
Motivation Epigenetic assays using next-generation sequencing (NGS) have furthered our
understanding of the functional genomic regions and the mechanisms of gene regulation …
understanding of the functional genomic regions and the mechanisms of gene regulation …