This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

Lung ischemia-reperfusion injury remains one of the major complications after cardiac
bypass surgery and lung transplantation. Due to its dual blood supply system and the …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

The transient receptor potential vallinoid type 4 (TRPV4) channel has been implicated in the
endothelial shear response and flow-mediated dilation, although the precise functions of this …

Background In blood vessels, the endothelium is a crucial signal transduction interface in
control of vascular tone and blood pressure to ensure energy and oxygen supply according …

Key points The endothelium plays a pivotal role in the vascular response to chemical and
mechanical stimuli. The endothelium is exquisitely sensitive to ACh, although the …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS …

Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the
risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects …