Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced
transformations in biological systems. Understanding their mode of action is essential for …

The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …

Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

The retina exhibits an inherent autofluorescence that is imaged ophthalmoscopically as
fundus autofluorescence. In clinical settings, fundus autofluorescence examination aids in …

Emerging evidence indicates that the autofluorescent pigments that accumulate as
lipofuscin in retinal pigment epithelial (RPE) cells may reach levels that contribute to a …

The photoreceptor/RPE complex must maintain a delicate balance between maximizing the
absorption of photons for vision and retinal image quality while simultaneously minimizing …

Human retinal dystrophies and degenerations and light-induced retinal degenerations in
animal models are sharing an important feature: visual cell death by apoptosis. Studying …

The pathogenesis of age‐related maculopathy (ARM), the most common cause of visual
loss after the age of 60 years, is indeed a complicated scenario that involves a variety of …

Visual perception occurs when radiation with a wavelength between 400 and 760 nm
reaches the retina. The retina has evolved to capture photons efficiently and initiate visual …

Oxidative stress represents one of the principal causes of inherited retinal dystrophies, with
many related molecular mechanisms still unknown. We investigated the posttranscriptional …