Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Summary N6-methyladenosine (m 6 A) is a crucial RNA modification that regulates diverse
biological processes in human cells, but its co-transcriptional deposition and functions …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

How transcription affects genome 3D organization is not well understood. We found that
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …

The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …

The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …

Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors.
To mitigate the stress-induced damage, cells activate transient survival programs. The heat …

Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …

The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a
central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in …