Mechanisms of increased bioavailability through amorphous solid dispersions: a review
Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble
drugs. However, their use in drug development is comparably rare due to a lack of basic …
drugs. However, their use in drug development is comparably rare due to a lack of basic …
Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers
J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
[BOOK][B] Fundamentals and applications of controlled release drug delivery
J Siepmann, RA Siegel, MJ Rathbone - 2012 - Springer
This book approaches the subject from a mechanistic perspective that pitches the language
at a level that is understandable to those entering the field and who are not familiar with its …
at a level that is understandable to those entering the field and who are not familiar with its …
Balancing solid-state stability and dissolution performance of lumefantrine amorphous solid dispersions: the role of polymer choice and drug–polymer interactions
Amorphous solid dispersions (ASDs) are of great interest due to their ability to enhance the
delivery of poorly soluble drugs. Recent studies have shown that, in addition to acting as a …
delivery of poorly soluble drugs. Recent studies have shown that, in addition to acting as a …
Amorphous solubility advantage: theoretical considerations, experimental methods, and contemporary relevance
Twenty-five years ago, Hancock and Parks asked a provocative question:“what is the true
solubility advantage for amorphous pharmaceuticals?” Difficulties in determining the …
solubility advantage for amorphous pharmaceuticals?” Difficulties in determining the …
Release mechanisms of amorphous solid dispersions: role of drug-polymer phase separation and morphology
Formulating poorly soluble molecules as amorphous solid dispersions (ASDs) is an effective
strategy to improve drug release. However, drug release rate and extent tend to rapidly …
strategy to improve drug release. However, drug release rate and extent tend to rapidly …
Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization, and glass …
Drug loading is an important parameter known to impact the release rate of a poorly soluble
drug from an amorphous solid dispersion (ASD). Recent studies have shown that small …
drug from an amorphous solid dispersion (ASD). Recent studies have shown that small …
Stable amorphous solid dispersion of flubendazole with high loading via electrospinning
J Becelaere, E Van Den Broeck, E Schoolaert… - Journal of Controlled …, 2022 - Elsevier
In this work, an important step is taken towards the bioavailability improvement of poorly
water-soluble drugs, such as flubendazole (Flu), posing a challenge in the current …
water-soluble drugs, such as flubendazole (Flu), posing a challenge in the current …
Dissolution mechanisms of amorphous solid dispersions: role of drug load and molecular interactions
High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate
partially because drug release is inhibited at high drug loads. The maximum drug load prior …
partially because drug release is inhibited at high drug loads. The maximum drug load prior …