A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

J Peng, M Fan, C An, F Ni, W Huang… - Basic & clinical …, 2022 - Wiley Online Library
Cannabidiol (CBD) is an abundant non‐psychoactive phytocannabinoid in cannabis
extracts which has high affinity on a series of receptors, including Type 1 cannabinoid …

Antioxidative and anti-inflammatory properties of cannabidiol

S Atalay, I Jarocka-Karpowicz, E Skrzydlewska - Antioxidants, 2019 - mdpi.com
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …

The pharmacoresistant epilepsy: an overview on existent and new emerging therapies

A Fattorusso, S Matricardi, E Mencaroni… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is one of the most common neurological chronic disorders, with an estimated
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …

Epilepsy in adults

RD Thijs, R Surges, TJ O'Brien, JW Sander - The lancet, 2019 - thelancet.com
Epilepsy is one of the most common serious brain conditions, affecting over 70 million
people worldwide. Its incidence has a bimodal distribution with the highest risk in infants and …

THC and CBD: Similarities and differences between siblings

N Stella - Neuron, 2023 - cell.com
Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

Cannabidiol inhibits Nav channels through two distinct binding sites

J Huang, X Fan, X **, S Jo, HB Zhang, A Fujita… - Nature …, 2023 - nature.com
Cannabidiol (CBD), a major non-psychoactive phytocannabinoid in cannabis, is an effective
treatment for some forms of epilepsy and pain. At high concentrations, CBD interacts with a …

Cannabidiol: pharmacology and therapeutic targets

SC Britch, S Babalonis, SL Walsh - Psychopharmacology, 2021 - Springer
Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

The role of glutamate receptors in epilepsy

TS Chen, TH Huang, MC Lai, CW Huang - Biomedicines, 2023 - mdpi.com
Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing
an indispensable role in neuronal development and memory formation. The dysregulation of …

Cannabidiol adverse effects and toxicity

MA Huestis, R Solimini, S Pichini… - Current …, 2019 - ingentaconnect.com
Background: Currently, there is a great interest in the potential medical use of cannabidiol
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD …

Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort

JD Symonds, SM Zuberi, K Stewart, A McLellan… - Brain, 2019 - academic.oup.com
Epilepsy is common in early childhood. In this age group it is associated with high rates of
therapy-resistance, and with cognitive, motor, and behavioural comorbidity. A large number …