Prevention of cardiovascular disease (CVD) remains one of the largest public health
challenges of our time. Identifying individuals at increased cardiovascular risk at an …

Despite the wide recognition of larger artery stiffness as a highly clinically relevant and
independent prognostic biomarker, it has yet be incorporated into routine clinical practice …

Ventricular–arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic
mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment …

Bicuspid aortic valve is the most common congenital heart disease and exposes patients to
an increased risk of aortic dilation and dissection. Aortic dilation is a slow, silent process …

Local pulse wave velocity (PWV) is evolving as one of the important determinants of arterial
hemodynamics, localized vessel stiffening associated with several pathologies, and a host …

Background Excess transmission of pressure pulsatility caused by increased arterial
stiffness may incur microcirculatory damage in end organs (target organ damage [TOD]) …

Abstract Purpose of Review Given that the life expectancy and the burden of hypertension
are projected to increase over the next decade, hypertensive heart disease (HHD) may be …

Aging of the vasculature, which is integral to the functioning of literally all human organs,
serves as a fundamental physiological basis for age-related alterations as well as a shared …

Diabetes mellitus is associated with endothelial dysfunction that leads to cardiovascular
complications. Sodium-glucose cotransporter 2 (SGLT2) inhibitors demonstrated efficacy in …

Magnetic resonance imaging and computed tomography allow the characterization of
arterial state and function with high confidence and thus play a key role in the understanding …