How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

The way in which interactions between mechanics and biochemistry lead to the emergence
of complex cell and tissue organization is an old question that has recently attracted …

Tissue flow during morphogenesis is commonly driven by local constriction of cell cortices,
which is caused by the activation of actomyosin contractility. This can lead to long-range …

During gastrulation, physical forces reshape the simple embryonic tissue to form the
complex body plans of multicellular organisms. These forces often cause large-scale …

Within develo** embryos, tissues flow and reorganize dramatically on timescales as short
as minutes. This includes epithelial tissues, which often narrow and elongate in convergent …

Tissue morphogenesis relies on the production of active cellular forces. Understanding how
such forces are mechanically converted into cell shape changes is essential to our …

Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism
during tissue folding in embryo development. While much is now understood of the …

Epithelial monolayers are two-dimensional cell sheets which compartmentalize the body
and organs of multicellular organisms. Their morphogenesis during development or …

Cell monolayers are a central model system in the study of tissue biophysics. In vivo,
epithelial tissues are curved on the scale of microns, and the curvature's role in the onset of …

Epithelial furrowing is a fundamental morphogenetic process during gastrulation,
neurulation, and body sha**. A furrow often results from a fold that propagates along a …