Triazoles and their derivatives: Chemistry, synthesis, and therapeutic applications
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …
Recent developments in mitogen activated protein kinase inhibitors as potential anticancer agents
The mitogen activated protein kinase (MAPK) belongs to group of kinase that links the
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …
Design, synthesis, molecular modeling, anticancer studies, and density functional theory calculations of 4-(1, 2, 4-triazol-3-ylsulfanylmethyl)-1, 2, 3-triazole derivatives
New conjugates of substituted 1, 2, 3-triazoles linked to 1, 2, 4-triazoles were synthesized
starting from the appropriate S-propargylated 1, 2, 4-triazoles 7 and 8. Ligation of 1, 2, 4 …
starting from the appropriate S-propargylated 1, 2, 4-triazoles 7 and 8. Ligation of 1, 2, 4 …
Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies
The discovery of potent STAT3 inhibitors has gained noteworthy impetus in the last decade.
In line with this trend, considering the proven biological importance of 1, 2, 4-triazoles …
In line with this trend, considering the proven biological importance of 1, 2, 4-triazoles …
Hetero-bimetallic transition metal-substituted Krebs-type polyoxometalate with N-chelating ligand as anticancer agents
HZ Zhang, HX Zhao, WH Chang, XY Liu, P Chen… - Tungsten, 2023 - Springer
A novel hetero-bimetallic transition metal (SbV/MnII)-substituted Krebs-type polyoxometalate
(POM) with N-chelating ligand H4Na4 [Mn4 (H2O) 4 (trz) 2 (SbO2) 2 (SbW9O33) 2]· 20H2O …
(POM) with N-chelating ligand H4Na4 [Mn4 (H2O) 4 (trz) 2 (SbO2) 2 (SbW9O33) 2]· 20H2O …
New 4-(arylidene) amino-1, 2, 4-traizole-5-thiol derivatives and their acyclo thioglycosides as α-glucosidase and α-amylase inhibitors: Design, synthesis, and …
Abstract A series of 1, 2, 4-triazole Schiffs bases 3-9 and their respective acyclo
thioglycosides 10-15 based α-glucosidase and α-amylase inhibitors were synthesized under …
thioglycosides 10-15 based α-glucosidase and α-amylase inhibitors were synthesized under …
Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1, 2, 4-triazole derivatives
Synthesis of bioactive heterocyclic compounds having effective biological activity is an
essential research area for wide-ranging applications. In this study, a conventional …
essential research area for wide-ranging applications. In this study, a conventional …
[HTML][HTML] Synthesis and structural proof of novel oxazolo [5, 4-d] pyrimidine derivatives as potential VEGFR2 inhibitors. In vitro study of their anticancer activity
A Sochacka-Ćwikła, A Regiec, Ż Czyżnikowska… - Bioorganic …, 2024 - Elsevier
The present study aimed to design and synthesize novel 6-N-benzyloxazolo [5, 4-d]
pyrimidin-7 (6H)-imines 3a-j as possible inhibitors of the vascular endothelial growth factor …
pyrimidin-7 (6H)-imines 3a-j as possible inhibitors of the vascular endothelial growth factor …
Synthesis, properties and biological potential some condensed derivatives 1, 2, 4-triazole
A Gotsulya, T Brytanova - Journal of Faculty of Pharmacy of Ankara …, 2022 - dergipark.org.tr
Objective: The aim of the work was to develop effective methods for the synthesis of
biologically active heterocyclic systems containing pyrrole, indole and 1, 2, 4-triazole. In this …
biologically active heterocyclic systems containing pyrrole, indole and 1, 2, 4-triazole. In this …
Novel semisynthetic betulinic acid− triazole hybrids with in vitro antiproliferative potential
Betulinic acid, BA, is a lupane derivative that has caught the interest of researchers due to
the wide variety of pharmacological properties it exhibits towards tumor cells. Because of …
the wide variety of pharmacological properties it exhibits towards tumor cells. Because of …