The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …

Bacteria are under immense evolutionary pressure from their viral invaders—
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …

Argonaute proteins use single-stranded RNA or DNA guides to target complementary
nucleic acids. This allows eukaryotic Argonaute proteins to mediate RNA interference and …

Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect
and cleave invader nucleic acids using complementary guides and the nuclease activities of …

Bacteria are under constant attack from bacteriophages (phages), bacterial parasites that
are the most abundant biological entity on earth. To resist phage infection, bacteria have …

Argonaute proteins (Agos) use small 15–30 nucleotide-long guides to bind and/or cleave
complementary target nucleic acids. Eukaryotic Agos mediate RNA-guided RNA silencing …

Both eukaryotes and prokaryotes (archaea and bacteria) encode an arsenal of immune
systems that protect the host against mobile genetic elements (MGEs) including viruses …

Members of the conserved Argonaute protein family use small RNA guides to locate their
mRNA targets and regulate gene expression and suppress mobile genetic elements in …

Although eukaryotic and long prokaryotic Argonaute proteins (pAgos) cleave nucleic acids,
some short pAgos lack nuclease activity and hydrolyse NAD (P)+ to induce bacterial cell …

Argonaute (Ago) proteins mediate RNA-or DNA-guided inhibition of nucleic acids,. Although
the mechanisms used by eukaryotic Ago proteins and long prokaryotic Ago proteins (pAgos) …