Cryptococcus neoformans and Cryptococcus gattii are the two etiologic agents of
cryptococcosis. They belong to the phylum Basidiomycota and can be readily distinguished …

Ca2+, as a second messenger in cells, enables organisms to adapt to different
environmental stresses by rapidly sensing and responding to external stimuli. In recent …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes approximately
625,000 deaths per year from nervous system infections. Here, we leveraged a unique …

Calcium transporters that mediate the removal of Ca2+ from the cytosol and into internal
stores provide a critical role in regulating Ca2+ signals following stimulus induction and in …

Fungi and animals constitute sister kingdoms in the eukaryotic domain of life. The major
classes of transporters, channels, sensors, and effectors that move and respond to calcium …

Zinc homeostasis is essential for fungal growth, as this metal is a critical structural
component of several proteins, including transcription factors. The fungal pathogen …

The key players of calcium (Ca2+) homeostasis and Ca2+ signal generation, which are
Ca2+ channels, Ca2+/H+ antiporters, and Ca2+-ATPases, are present in all fungi. Their …

Secretion of virulence factors is a critical mechanism for the establishment of cryptococcosis,
a disease caused by the yeast pathogen Cryptococcus neoformans. One key virulence …

Cryptococcus neoformans, an opportunistic yeast pathogen, relies on a complex network of
stress response pathways that allow for proliferation in the host. In Saccharomyces …

Ureases (EC 3.5. 1.5) are Ni2+‐dependent metalloenzymes produced by plants, fungi and
bacteria that hydrolyze urea to produce ammonia and CO2. The insertion of nickel atoms …