ABSTRACT Introduction: Dry powder inhalers (DPIs) are popular for pulmonary drug
delivery. Various techniques have been employed to produce inhalation drug particles and …

Respiratory infections represent a major global health problem. They are often treated by
parenteral administrations of antimicrobials. Unfortunately, systemic therapies of high-dose …

Novel inhaled therapeutics including antibiotics, vaccines and anti-hypertensives, have led
to innovations in designing suitable delivery systems. These emerging design technologies …

Lung cancer is the second most prevalent and the deadliest among all cancer types.
Chemotherapy is recommended for lung cancers to control tumor growth and to prolong …

Pulmonary delivery of lipid-based nanotherapeutics by inhalation presents an
advantageous alternative to oral and intravenous routes of administration that avoids …

Simultaneous micronization and surface modification of drug particles is considered in order
to mitigate disadvantages of micronization, eg, agglomeration, poor flowability, marginal …

Understanding interparticle interactions in powder systems is crucial to pharmaceutical
powder processing. Nevertheless, there remains a great challenge in identifying the key …

Dry powder inhalers have become increasingly attractive for pulmonary delivery of locally
and systemically effective medications. In comparison to the liquid counterparts, such as …

For dry powder inhaler formulations, micronized drug powders are commonly mixed with
coarse lactose carriers to facilitate powder handling during the manufacturing and powder …

The purpose of this study was to evaluate the effect of carrier particle size on properties of
dry powder and its effect on dry powder inhaler (DPI) performance. Commercial α-lactose …